- Reduced Verbal Fluency following Subthalamic Deep Brain. -
- Aleksandri Andrevich Baranov Encyclopedia Arctica 15
- Cell Death and Differentiation - A novel mechanism of CD40
- The Beale papers - [email protected]
Reduced Verbal Fluency following Subthalamic Deep Brain. -
Membrane-presented CD40 agonists can induce apoptosis in carcinoma, but not normal homologous epithelial cells, whereas soluble agonists are growth inhibitory but not proapoptotic unless protein synthesis is blocked.
Aleksandri Andrevich Baranov Encyclopedia Arctica 15
Here we demonstrate that membrane-presented CD40 land (CD154) (m CD40L), but not soluble agonists, trgers cell death in malnant human urothelial cells via a direct mechanism involving rapid upregulation of TNFR-associated factor (TRAF)3 protein, without concomitant upregulation of TRAF3 m RNA, followed by activation of the c-Jun N-terminal kinase (JNK)/activator protein-1 (AP-1) pathway and induction of the caspase-9/caspase-3-associated intrinsic apoptotic machinery.
Cell Death and Differentiation - A novel mechanism of CD40
Thus, TRAF3 stabilization, JNK activation and caspase-9 induction define a novel pathway of CD40-mediated apoptosis in carcinoma cells.
The Beale papers - [email protected]
TRAF3 knockdown abrogated JNK/AP-1 activation and prevented CD40-mediated apoptosis, whereas restoration of CD40 expression in CD40-negative carcinoma cells restored apoptotic susceptibility via the TRAF3/AP-1-dependent mechanism.
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